Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.

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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_7A5968ADA94D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Journal
Frontiers in immunology
Author(s)
Juilland M., Thome M.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Pages
1927
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
The scaffold proteins CARMA1-3 (encoded by the genes CARD11, -14 and -10) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine kinases (RTK). These receptors trigger the formation of oligomeric CARMA/CARD-BCL10-MALT1 (CBM) complexes via kinases of the PKC family. The CBM in turn regulates gene expression by the activation of NF-κB and AP-1 transcription factors and controls transcript stability. The paracaspase MALT1 is the only CBM component having an enzymatic (proteolytic) activity and has therefore recently gained attention as a potential drug target. Here we review recent advances in the understanding of the molecular function of the protease MALT1 and summarize how MALT1 scaffold and protease function contribute to the transmission of CBM signals. Finally, we will highlight how dysregulation of MALT1 function can cause pathologies such as immunodeficiency, autoimmunity, psoriasis, and cancer.
Keywords
Autoimmune Diseases/immunology, Autoimmune Diseases/therapy, CARD Signaling Adaptor Proteins/immunology, Common Variable Immunodeficiency/immunology, Common Variable Immunodeficiency/pathology, Common Variable Immunodeficiency/therapy, Humans, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/immunology, NF-kappa B/immunology, Neoplasm Proteins/immunology, Neoplasms/immunology, Neoplasms/pathology, Neoplasms/therapy, Signal Transduction/immunology, Transcription Factor AP-1/immunology, BCR, EGFR, GPCR, RNA stability, TCR, Treg, paracaspase, ubiquitin
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2018 7:43
Last modification date
28/09/2019 5:08
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