Effects of sodium lactate on ventilation and acid-base balance in healthy humans

Détails

ID Serval
serval:BIB_799FD48C782D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of sodium lactate on ventilation and acid-base balance in healthy humans
Périodique
Clinical Physiology
Auteur⸱e⸱s
Tappy  L., Cayeux  M. C., Chiolero  R.
ISSN
0144-5979 (Print)
Statut éditorial
Publié
Date de publication
07/1996
Volume
16
Numéro
4
Pages
393-401
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
Sodium lactate inhibits ventilation when infused in healthy human subjects. This effect has been attributed to lactate-induced metabolic alkalosis. In order to further delineate the mechanisms responsible for this depression of ventilation, healthy humans were infused with sodium lactate with or without acetazolamide. Sodium lactate increased blood pH from 7.37 +/- 0.02 to 7.47 +/- 0.01 and induced a sustained urinary excretion of bicarbonate. PO2 of arterialized blood decreased by 10.3 +/- 2.1 mmHg, indicating an inhibition of ventilation. Acetazolamide decreased lactate-induced alkalinisation of blood (pH after lactate + acetazolamide 7.42 +/- 0.02), but did not prevent the drop in PO2. Acetazolamide alone tended to stimulate ventilation, as indicated by an increase in PO2. These results indicate that sodium lactate inhibits ventilation independently of changes in systemic blood pH. Alkalinization of the cerebrospinal fluid, or other central effects of lactate, is probably responsible for this ventilatory depression.
Mots-clé
Acetazolamide/administration & dosage/pharmacology Acid-Base Equilibrium/*drug effects Adult Alkalosis/chemically induced/drug therapy/*metabolism Blood Gas Analysis Carbonic Anhydrase Inhibitors/administration & dosage/pharmacology Drug Combinations Humans Hydrogen-Ion Concentration Infusions, Intravenous Male Reference Values Respiration/*drug effects/physiology Sodium Bicarbonate/urine Sodium Lactate/administration & dosage/*pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 13:36
Dernière modification de la notice
20/08/2019 14:36
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