Effects of sodium lactate on ventilation and acid-base balance in healthy humans
Details
Serval ID
serval:BIB_799FD48C782D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of sodium lactate on ventilation and acid-base balance in healthy humans
Journal
Clinical Physiology
ISSN
0144-5979 (Print)
Publication state
Published
Issued date
07/1996
Volume
16
Number
4
Pages
393-401
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Sodium lactate inhibits ventilation when infused in healthy human subjects. This effect has been attributed to lactate-induced metabolic alkalosis. In order to further delineate the mechanisms responsible for this depression of ventilation, healthy humans were infused with sodium lactate with or without acetazolamide. Sodium lactate increased blood pH from 7.37 +/- 0.02 to 7.47 +/- 0.01 and induced a sustained urinary excretion of bicarbonate. PO2 of arterialized blood decreased by 10.3 +/- 2.1 mmHg, indicating an inhibition of ventilation. Acetazolamide decreased lactate-induced alkalinisation of blood (pH after lactate + acetazolamide 7.42 +/- 0.02), but did not prevent the drop in PO2. Acetazolamide alone tended to stimulate ventilation, as indicated by an increase in PO2. These results indicate that sodium lactate inhibits ventilation independently of changes in systemic blood pH. Alkalinization of the cerebrospinal fluid, or other central effects of lactate, is probably responsible for this ventilatory depression.
Keywords
Acetazolamide/administration & dosage/pharmacology
Acid-Base Equilibrium/*drug effects
Adult
Alkalosis/chemically induced/drug therapy/*metabolism
Blood Gas Analysis
Carbonic Anhydrase Inhibitors/administration & dosage/pharmacology
Drug Combinations
Humans
Hydrogen-Ion Concentration
Infusions, Intravenous
Male
Reference Values
Respiration/*drug effects/physiology
Sodium Bicarbonate/urine
Sodium Lactate/administration & dosage/*pharmacology
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 14:36