Plasticity in the barrel cortex of the adult mouse: effects of peripheral deprivation on GAD-immunoreactivity

Détails

ID Serval
serval:BIB_794B8313C117
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Plasticity in the barrel cortex of the adult mouse: effects of peripheral deprivation on GAD-immunoreactivity
Périodique
Experimental Brain Research
Auteur⸱e⸱s
Welker  E., Soriano  E., Van der Loos  H.
ISSN
0014-4819 (Print)
Statut éditorial
Publié
Date de publication
1989
Volume
74
Numéro
3
Pages
441-52
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
The whisker-to-barrel pathway of the adult mouse was used in a study on the effects of peripheral sensory deprivation on GAD-immunoreactivity in the somatosensory cortex. At varying periods of time after removal of a set of vibrissal follicles, mice were processed for immunohistochemistry using an antibody against GAD. In sections tangential to the cortical surface we observed, in the barrels whose follicles were removed, decreased immunoreactivity as early as three days after surgery. The decrease was due to a lesser numerical density of stained puncta and to less intense staining of those remaining. GAD-positive somata were also less intensely stained, whereas their number did not seem to be changed. The changes, apparent at 3 days after the surgery, were restricted to the barrels corresponding to the removed follicles and were maximal at 2-4 weeks. At longer survival times (until 7 months) the immunoreactivity returned to normal, coincident with the regeneration of peripheral nerve fibres in the absence of their follicles. We conclude that GAD-immunoreactivity in the barrel cortex swiftly reacts to modifications of neuronal activity evoked in the periphery.
Mots-clé
Afferent Pathways/physiology Animals Glutamate Decarboxylase/*metabolism Mice *Neuronal Plasticity Neurons, Afferent/enzymology/*physiology Somatosensory Cortex/enzymology/*physiology Vibrissae/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 14:40
Dernière modification de la notice
20/08/2019 14:35
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