Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels.

Détails

ID Serval
serval:BIB_774B96501C47
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels.
Périodique
Journal of Experimental Medicine
Auteur⸱e⸱s
Aguet M., Andersson L.C., Andersson R., Wight E., Binz H., Wigzell H.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1978
Volume
147
Numéro
1
Pages
50-61
Langue
anglais
Résumé
T lymphoblasts specific for foreign histocompatibility antigens and purified via mixed leukocyte culture (MLC) and 1 g velocity sedimentation procedures can be used as autoimmunogen to produce specific immunological unresponsiveness in adult animals. This unresponsiveness is positively correlated to the production of autoanti-idiotypic antibodies in the blast immunized animals and no evidence of coexisting alloimmunity was found. We consider this autoanti-idiotypic immunity to be the specific inducing agent of the immune tolerance. The blast immunization procedure will lead to selective reduction in T-cell reactivity against the relevant alloantigens as measured by MLC, cell-mediated lympholysis, or graft-versus-host assays. However, in individual animals, dichtomy in suppression between two T-cell assays could sometimes be observed indicating elimination of only a select group of idiotypic functionally distinct population of T cells in these blast-immunized animals. Attempts to abrogate already immune animals by the autoblast procedure were successful, in part suggesting the use of the present procedure when trying to induce in accelerated reversion of such immunity.
Mots-clé
Animals, Antibodies, Anti-Idiotypic, Antigens, Autoantibodies, Autoantigens, Epitopes, Histocompatibility Antigens, Immune Tolerance, Immunoglobulins, Immunosuppression, Lymphocyte Culture Test, Mixed, Mice, Mice, Inbred Strains, Rats, Rats, Inbred Strains, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 15:34
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