A cell cycle regulator potentially involved in genesis of many tumor types.

Détails

ID Serval
serval:BIB_70FA999E8623
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A cell cycle regulator potentially involved in genesis of many tumor types.
Périodique
Science
Auteur(s)
Kamb A., Gruis N.A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S.V., Stockert E., Day R.S., Johnson B.E., Skolnick M.H.
ISSN
0036-8075[print], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
04/1994
Volume
264
Numéro
5157
Pages
436-440
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
Mots-clé
Base Sequence, Carrier Proteins/genetics, Cell Cycle, Chromosomes, Human, Pair 9, Cosmids, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinases, Exons, Gene Deletion, Genes, Tumor Suppressor, Humans, Introns, Melanoma/genetics, Molecular Sequence Data, Mutation, Neoplasms/genetics, Protein Kinase Inhibitors, Proto-Oncogene Proteins, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
24/01/2008 15:33
Dernière modification de la notice
20/08/2019 14:29
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