A cell cycle regulator potentially involved in genesis of many tumor types.

Details

Serval ID
serval:BIB_70FA999E8623
Type
Article: article from journal or magazin.
Collection
Publications
Title
A cell cycle regulator potentially involved in genesis of many tumor types.
Journal
Science
Author(s)
Kamb A., Gruis N.A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S.V., Stockert E., Day R.S., Johnson B.E., Skolnick M.H.
ISSN
0036-8075[print], 0036-8075[linking]
Publication state
Published
Issued date
04/1994
Volume
264
Number
5157
Pages
436-440
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
Keywords
Base Sequence, Carrier Proteins/genetics, Cell Cycle, Chromosomes, Human, Pair 9, Cosmids, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinases, Exons, Gene Deletion, Genes, Tumor Suppressor, Humans, Introns, Melanoma/genetics, Molecular Sequence Data, Mutation, Neoplasms/genetics, Protein Kinase Inhibitors, Proto-Oncogene Proteins, Tumor Cells, Cultured
Pubmed
Web of science
Create date
24/01/2008 15:33
Last modification date
20/08/2019 14:29
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