Absence of ectopic epithelial inclusions in 3,904 axillary lymph nodes examined in sentinel technique.

Détails

Ressource 1Télécharger: serval:BIB_6F28649497D4.P001 (159.96 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_6F28649497D4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Absence of ectopic epithelial inclusions in 3,904 axillary lymph nodes examined in sentinel technique.
Périodique
Breast Cancer Research and Treatment
Auteur(s)
Iken S., Schmidt M., Braun C., Valentino A., Lehr H.A., Schaefer S.C.
ISSN
1573-7217 (Electronic)
ISSN-L
0167-6806
Statut éditorial
Publié
Date de publication
12/2011
Peer-reviewed
Oui
Volume
-
Numéro
-
Pages
-
Langue
anglais
Résumé
Intraoperative examination of sentinel axillary lymph nodes can be done by imprint cytology, frozen section, or, most recently, by PCR-based amplification of a cytokeratin signal. Using this technique, benign epithelial inclusions, representing mammary tissue displaced along the milk line, will likely generate a positive PCR signal and lead to a false-positive diagnosis of metastatic disease. To better appreciate the incidence of ectopic epithelial inclusions in axillary lymph nodes, we have performed an autopsy study, examining on 100 μm step sections 3,904 lymph nodes obtained from 160 axillary dissections in 80 patients. The median number of lymph nodes per axilla was 23 (15, 6, and 1 in levels 1, 2, and 3, respectively). A total of 30,450 hematoxylin-eosin stained slides were examined, as well as 8,825 slides immunostained with pan-cytokeratin antibodies. Despite this meticulous work-up, not a single epithelial inclusion was found in this study, suggesting that the incidence of such inclusions is much lower than the assumed 5% reported in the literature.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/12/2011 9:04
Dernière modification de la notice
01/10/2019 6:18
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