Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

Détails

ID Serval
serval:BIB_6EF7F1FB8F37
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Wang B., André I., Gonzalez A., Katz J.D., Aguet M., Benoist C., Mathis D.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1997
Volume
94
Numéro
25
Pages
13844-13849
Langue
anglais
Résumé
The role of interferon-gamma in autoimmune diabetes was assessed by breeding a null mutation of the interferon-gamma receptor alpha chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-gamma gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhibition of insulitis-both the kinetics and penetrance-and no signs of diabetes; the transgenic model exhibited near-normal insulitis, but this never evolved into diabetes, either spontaneously or after experimental provocation. This failure could not be explained by perturbations in the ratio of T helper cell phenotypes; rather, it reflected a defect in antigen-presenting cells or in the islet beta cell targets.
Mots-clé
Animals, Antigen-Presenting Cells/immunology, Diabetes Mellitus, Type 1/etiology, Diabetes Mellitus, Type 1/immunology, Female, Interferon-gamma/physiology, Islets of Langerhans/immunology, Male, Mice, Mice, Inbred NOD, Mice, Mutant Strains, Mice, Transgenic, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/physiology, Receptors, Interferon/genetics, Receptors, Interferon/physiology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:36
Dernière modification de la notice
20/08/2019 14:28
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