Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

Details

Serval ID
serval:BIB_6EF7F1FB8F37
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Wang B., André I., Gonzalez A., Katz J.D., Aguet M., Benoist C., Mathis D.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1997
Volume
94
Number
25
Pages
13844-13849
Language
english
Abstract
The role of interferon-gamma in autoimmune diabetes was assessed by breeding a null mutation of the interferon-gamma receptor alpha chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-gamma gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhibition of insulitis-both the kinetics and penetrance-and no signs of diabetes; the transgenic model exhibited near-normal insulitis, but this never evolved into diabetes, either spontaneously or after experimental provocation. This failure could not be explained by perturbations in the ratio of T helper cell phenotypes; rather, it reflected a defect in antigen-presenting cells or in the islet beta cell targets.
Keywords
Animals, Antigen-Presenting Cells/immunology, Diabetes Mellitus, Type 1/etiology, Diabetes Mellitus, Type 1/immunology, Female, Interferon-gamma/physiology, Islets of Langerhans/immunology, Male, Mice, Mice, Inbred NOD, Mice, Mutant Strains, Mice, Transgenic, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/physiology, Receptors, Interferon/genetics, Receptors, Interferon/physiology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:36
Last modification date
20/08/2019 14:28
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