Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Details
Serval ID
serval:BIB_6EF7F1FB8F37
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1997
Volume
94
Number
25
Pages
13844-13849
Language
english
Abstract
The role of interferon-gamma in autoimmune diabetes was assessed by breeding a null mutation of the interferon-gamma receptor alpha chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-gamma gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhibition of insulitis-both the kinetics and penetrance-and no signs of diabetes; the transgenic model exhibited near-normal insulitis, but this never evolved into diabetes, either spontaneously or after experimental provocation. This failure could not be explained by perturbations in the ratio of T helper cell phenotypes; rather, it reflected a defect in antigen-presenting cells or in the islet beta cell targets.
Keywords
Animals, Antigen-Presenting Cells/immunology, Diabetes Mellitus, Type 1/etiology, Diabetes Mellitus, Type 1/immunology, Female, Interferon-gamma/physiology, Islets of Langerhans/immunology, Male, Mice, Mice, Inbred NOD, Mice, Mutant Strains, Mice, Transgenic, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/physiology, Receptors, Interferon/genetics, Receptors, Interferon/physiology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:36
Last modification date
20/08/2019 15:28