Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.

Détails

Ressource 1Télécharger: Neyroud et al. 2023-MuRF1.pdf (5502.25 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Document(s) secondaire(s)
Télécharger: Neyroud et al. 2023-MuRF1 supp fig.pdf (195.24 [Ko])
Etat: Public
Version: Supplementary document
Licence: Non spécifiée
ID Serval
serval:BIB_6DBB6800EF47
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Périodique
Communications biology
Auteur⸱e⸱s
Neyroud D., Laitano O., Dasgupta A., Lopez C., Schmitt R.E., Schneider J.Z., Hammers D.W., Sweeney H.L., Walter G.A., Doles J., Judge S.M., Judge A.R.
ISSN
2399-3642 (Electronic)
ISSN-L
2399-3642
Statut éditorial
Publié
Date de publication
13/05/2023
Peer-reviewed
Oui
Volume
6
Numéro
1
Pages
519
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigate the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC) cells, or saline, were injected into the pancreas of WT and MuRF1 <sup>-/-</sup> mice, and tissues analyzed throughout tumor progression. KPC tumors induces progressive wasting of skeletal muscle and systemic metabolic reprogramming in WT mice, but not MuRF1 <sup>-/-</sup> mice. KPC tumors from MuRF1 <sup>-/-</sup> mice also grow slower, and show an accumulation of metabolites normally depleted by rapidly growing tumors. Mechanistically, MuRF1 is necessary for the KPC-induced increases in cytoskeletal and muscle contractile protein ubiquitination, and the depression of proteins that support protein synthesis. Together, these data demonstrate that MuRF1 is required for KPC-induced skeletal muscle wasting, whose deletion reprograms the systemic and tumor metabolome and delays tumor growth.
Mots-clé
Animals, Mice, Muscle, Skeletal/metabolism, Muscular Atrophy/genetics, Pancreas/metabolism, Pancreatic Neoplasms/genetics, Pancreatic Neoplasms/metabolism, Quality of Life, Ubiquitin-Protein Ligases/genetics, Ubiquitin-Protein Ligases/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/05/2023 8:56
Dernière modification de la notice
18/07/2024 7:07
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