Inflation comes before the fall: How epithelial stretch drives crypt fission.
Détails
ID Serval
serval:BIB_6CDFDA93476A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inflation comes before the fall: How epithelial stretch drives crypt fission.
Périodique
Cell stem cell
ISSN
1875-9777 (Electronic)
ISSN-L
1875-9777
Statut éditorial
Publié
Date de publication
02/09/2021
Peer-reviewed
Oui
Volume
28
Numéro
9
Pages
1505-1506
Langue
anglais
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Publication Status: ppublish
Résumé
In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.
Mots-clé
Cell Count, Epithelial Cells, Organoids
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/01/2024 11:14
Dernière modification de la notice
13/01/2024 8:10