Inflation comes before the fall: How epithelial stretch drives crypt fission.

Details

Serval ID
serval:BIB_6CDFDA93476A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Inflation comes before the fall: How epithelial stretch drives crypt fission.
Journal
Cell stem cell
Author(s)
Jowett G.M., Gentleman E.
ISSN
1875-9777 (Electronic)
ISSN-L
1875-9777
Publication state
Published
Issued date
02/09/2021
Peer-reviewed
Oui
Volume
28
Number
9
Pages
1505-1506
Language
english
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Abstract
In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.
Keywords
Cell Count, Epithelial Cells, Organoids
Pubmed
Web of science
Open Access
Yes
Create date
12/01/2024 11:14
Last modification date
13/01/2024 8:10
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