Linkage analysis of families with severe childhood autosomal recessive muscular dystrophy in Morocco indicates genetic homogeneity of the disease in north Africa

Détails

ID Serval
serval:BIB_690822DBA226
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Linkage analysis of families with severe childhood autosomal recessive muscular dystrophy in Morocco indicates genetic homogeneity of the disease in north Africa
Périodique
Journal of Medical Genetics
Auteur⸱e⸱s
el Kerch  F., Sefiani  A., Azibi  K., Boutaleb  N., Yahyaoui  M., Bentahila  A., Vinet  M. C., Leturcq  F., Bachner  L., Beckmann  J., Campbell  K.P., Tome  F.M.S., Fardeau  M., Kaplan  J.C.
ISSN
0022-2593 (Print)
Statut éditorial
Publié
Date de publication
04/1994
Volume
31
Numéro
4
Pages
342-3
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
It has been previously shown in Tunisian and Algerian families that the locus for SCARMD maps to the proximal part of 13q, and in Algerian families that the disease is associated with deficiency of the 50 kDa dystrophin associated glycoprotein (50DAG). We have tested this linkage in six families from Morocco where this disease is also prevalent. In one family the 50DAG was tested and found to be negative in a muscle biopsy. Our results showed similar linkage in this country, with statistical tests indicating genetic homogeneity between the three Maghreb countries.
Mots-clé
Algeria Child Chromosomes, Human, Pair 13 Consanguinity Cytoskeletal Proteins/*genetics Female *Genes, Recessive Humans Lod Score Male Membrane Glycoproteins/*genetics Morocco/epidemiology Muscular Dystrophies/epidemiology/*ethnology/*genetics Pedigree Sarcoglycans Tunisia
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:17
Dernière modification de la notice
20/08/2019 15:24
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