Linkage analysis of families with severe childhood autosomal recessive muscular dystrophy in Morocco indicates genetic homogeneity of the disease in north Africa

Details

Request a copyRequest a copy
Serval ID
serval:BIB_690822DBA226
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Linkage analysis of families with severe childhood autosomal recessive muscular dystrophy in Morocco indicates genetic homogeneity of the disease in north Africa
Journal
Journal of Medical Genetics
Author(s)
el Kerch  F., Sefiani  A., Azibi  K., Boutaleb  N., Yahyaoui  M., Bentahila  A., Vinet  M. C., Leturcq  F., Bachner  L., Beckmann  J., Campbell  K.P., Tome  F.M.S., Fardeau  M., Kaplan  J.C.
ISSN
0022-2593 (Print)
Publication state
Published
Issued date
04/1994
Volume
31
Number
4
Pages
342-3
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
It has been previously shown in Tunisian and Algerian families that the locus for SCARMD maps to the proximal part of 13q, and in Algerian families that the disease is associated with deficiency of the 50 kDa dystrophin associated glycoprotein (50DAG). We have tested this linkage in six families from Morocco where this disease is also prevalent. In one family the 50DAG was tested and found to be negative in a muscle biopsy. Our results showed similar linkage in this country, with statistical tests indicating genetic homogeneity between the three Maghreb countries.
Keywords
Algeria Child Chromosomes, Human, Pair 13 Consanguinity Cytoskeletal Proteins/*genetics Female *Genes, Recessive Humans Lod Score Male Membrane Glycoproteins/*genetics Morocco/epidemiology Muscular Dystrophies/epidemiology/*ethnology/*genetics Pedigree Sarcoglycans Tunisia
OAI-PMH
oai:serval.unil.ch:BIB_690822DBA226
DOI
10.1136/jmg.31.4.342
Pubmed
8071965
Web of science
A1994NH06100016
Open Access
Yes
Create date
25/01/2008 17:17
Last modification date
20/08/2019 15:24
Usage data