Traitement antibiotique oral des neutropenies febriles en onco-hematologie. L'experience du groupe antimicrobien de l'EORTC. [Treatment with oral antibiotics of febrile neutropenia in onco-haematology. The experience of the EORTC antimicrobial group]
Détails
ID Serval
serval:BIB_67BB6D268DE0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Traitement antibiotique oral des neutropenies febriles en onco-hematologie. L'experience du groupe antimicrobien de l'EORTC. [Treatment with oral antibiotics of febrile neutropenia in onco-haematology. The experience of the EORTC antimicrobial group]
Périodique
Presse Médicale
ISSN
0755-4982 (Print)
Statut éditorial
Publié
Date de publication
03/2004
Volume
33
Numéro
5
Pages
327-9
Notes
Comparative Study
English Abstract
Journal Article
Review --- Old month value: Mar 13
English Abstract
Journal Article
Review --- Old month value: Mar 13
Résumé
THE CONTEXT: Up until the nineties, the intravenous administration of a broad spectrum antibiotic was the classical treatment of any patient presenting with febrile neutropenia. Since then, in patients considered at low risk and with expected of neutropenia less than 7-10 days, oral antibiotherapy has become an attractive option. TWO LARGE STUDIES: A study by the antimicrobial group of the EORTC (European organisation for research and treatment of cancer) and a North American study have compared the efficacy of an oral combination of ciprofloxacine and amoxicillin/clavulanic acid with that of an intravenous antibiotherapy in low-risk patients presenting febrile neutropenia. In both studies, the success rate was the same in the group of patients treated with oral antibiotics and those treated with intravenous antibiotics. RESERVATIONS: These two studies were conducted in hospitalised patients. No conclusions can be drawn with regard to out-patient treatment. Out-patient management would only be possible after appropriate selection of patients at low risk.
Mots-clé
Administration, Oral
Amoxicillin-Potassium Clavulanate Combination/administration &
dosage/therapeutic use
Bacterial Infections/complications/*drug therapy
Ceftazidime/administration & dosage/therapeutic use
Ciprofloxacin/administration & dosage/therapeutic use
Drug Therapy, Combination/administration & dosage/*therapeutic use
Europe
Fever/*etiology
Hematologic Neoplasms/complications/immunology
Humans
Immunocompromised Host
Infusions, Intravenous
Inpatients
Multicenter Studies
Neoplasms/*complications/immunology
Neutropenia/*complications
Randomized Controlled Trials
Risk
Treatment Outcome
United States
Pubmed
Web of science
Création de la notice
25/01/2008 14:31
Dernière modification de la notice
20/08/2019 15:23