Traitement antibiotique oral des neutropenies febriles en onco-hematologie. L'experience du groupe antimicrobien de l'EORTC. [Treatment with oral antibiotics of febrile neutropenia in onco-haematology. The experience of the EORTC antimicrobial group]
Details
Serval ID
serval:BIB_67BB6D268DE0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Traitement antibiotique oral des neutropenies febriles en onco-hematologie. L'experience du groupe antimicrobien de l'EORTC. [Treatment with oral antibiotics of febrile neutropenia in onco-haematology. The experience of the EORTC antimicrobial group]
Journal
Presse Médicale
ISSN
0755-4982 (Print)
Publication state
Published
Issued date
03/2004
Volume
33
Number
5
Pages
327-9
Notes
Comparative Study
English Abstract
Journal Article
Review --- Old month value: Mar 13
English Abstract
Journal Article
Review --- Old month value: Mar 13
Abstract
THE CONTEXT: Up until the nineties, the intravenous administration of a broad spectrum antibiotic was the classical treatment of any patient presenting with febrile neutropenia. Since then, in patients considered at low risk and with expected of neutropenia less than 7-10 days, oral antibiotherapy has become an attractive option. TWO LARGE STUDIES: A study by the antimicrobial group of the EORTC (European organisation for research and treatment of cancer) and a North American study have compared the efficacy of an oral combination of ciprofloxacine and amoxicillin/clavulanic acid with that of an intravenous antibiotherapy in low-risk patients presenting febrile neutropenia. In both studies, the success rate was the same in the group of patients treated with oral antibiotics and those treated with intravenous antibiotics. RESERVATIONS: These two studies were conducted in hospitalised patients. No conclusions can be drawn with regard to out-patient treatment. Out-patient management would only be possible after appropriate selection of patients at low risk.
Keywords
Administration, Oral
Amoxicillin-Potassium Clavulanate Combination/administration &
dosage/therapeutic use
Bacterial Infections/complications/*drug therapy
Ceftazidime/administration & dosage/therapeutic use
Ciprofloxacin/administration & dosage/therapeutic use
Drug Therapy, Combination/administration & dosage/*therapeutic use
Europe
Fever/*etiology
Hematologic Neoplasms/complications/immunology
Humans
Immunocompromised Host
Infusions, Intravenous
Inpatients
Multicenter Studies
Neoplasms/*complications/immunology
Neutropenia/*complications
Randomized Controlled Trials
Risk
Treatment Outcome
United States
Pubmed
Web of science
Create date
25/01/2008 14:31
Last modification date
20/08/2019 15:23