Single-dose rifampin prophylaxis for experimental endocarditis induced by high bacterial inocula of viridans streptococci

Détails

Ressource 1Télécharger: serval:BIB_67B2BE812684.P001 (662.97 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_67B2BE812684
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Single-dose rifampin prophylaxis for experimental endocarditis induced by high bacterial inocula of viridans streptococci
Périodique
Journal of Infectious Diseases
Auteur(s)
Malinverni  R., Bille  J., Glauser  M. P.
ISSN
0022-1899
Statut éditorial
Publié
Date de publication
07/1987
Peer-reviewed
Oui
Volume
156
Numéro
1
Pages
151-7
Langue
anglais
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
In rats challenged with viridans streptococci poorly susceptible to antibiotic killing, single doses of antibiotics only prevent endocarditis induced by bacterial inoculum sizes that produce disease in 90% of control animals (ID90): additional doses are required to protect against inocula exceeding the ID90. We investigated whether single-dose rifampin would extend the efficacy of single-dose prophylaxis to inocula exceeding the ID90. We used two strains of viridans streptococci highly susceptible to killing by rifampin and two resistant strains. All rats were injected with 10-1,000 times the ID90 of the four strains. Single-dose rifampin successfully prevented endocarditis due to all four strains. A few prophylaxis failures were observed after challenge with the two poorly susceptible strains, but in vivo emergence of resistant variants did not account for these failures. Thus, rifampin was the first antibiotic given as a single dose that successfully prevented experimental streptococcus endocarditis after challenge with high bacterial inocula.
Mots-clé
Adhesiveness Animals Blood Platelets/microbiology Drug Resistance, Microbial Endocarditis, Bacterial/*prevention & control Female Microbial Sensitivity Tests Rats Rats, Inbred Strains Rifampin/*administration & dosage/blood Streptococcal Infections/*prevention & control Streptococcus/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2008 13:40
Dernière modification de la notice
01/10/2019 7:18
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