Single-dose rifampin prophylaxis for experimental endocarditis induced by high bacterial inocula of viridans streptococci

Details

Ressource 1Download: serval:BIB_67B2BE812684.P001 (662.97 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_67B2BE812684
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Single-dose rifampin prophylaxis for experimental endocarditis induced by high bacterial inocula of viridans streptococci
Journal
Journal of Infectious Diseases
Author(s)
Malinverni  R., Bille  J., Glauser  M. P.
ISSN
0022-1899
Publication state
Published
Issued date
07/1987
Peer-reviewed
Oui
Volume
156
Number
1
Pages
151-7
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
In rats challenged with viridans streptococci poorly susceptible to antibiotic killing, single doses of antibiotics only prevent endocarditis induced by bacterial inoculum sizes that produce disease in 90% of control animals (ID90): additional doses are required to protect against inocula exceeding the ID90. We investigated whether single-dose rifampin would extend the efficacy of single-dose prophylaxis to inocula exceeding the ID90. We used two strains of viridans streptococci highly susceptible to killing by rifampin and two resistant strains. All rats were injected with 10-1,000 times the ID90 of the four strains. Single-dose rifampin successfully prevented endocarditis due to all four strains. A few prophylaxis failures were observed after challenge with the two poorly susceptible strains, but in vivo emergence of resistant variants did not account for these failures. Thus, rifampin was the first antibiotic given as a single dose that successfully prevented experimental streptococcus endocarditis after challenge with high bacterial inocula.
Keywords
Adhesiveness Animals Blood Platelets/microbiology Drug Resistance, Microbial Endocarditis, Bacterial/*prevention & control Female Microbial Sensitivity Tests Rats Rats, Inbred Strains Rifampin/*administration & dosage/blood Streptococcal Infections/*prevention & control Streptococcus/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2008 13:40
Last modification date
01/10/2019 7:18
Usage data