Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.
Détails
ID Serval
serval:BIB_654FBC87007F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.
Périodique
Journal of Clinical Psychopharmacology
ISSN
0271-0749 (Print)
ISSN-L
0271-0749
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
17
Numéro
2
Pages
113-117
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Six and seven addicts treated with racemic methadone (MTD) were comedicated with fluvoxamine (FLV) and fluoxetine (FLX), respectively. The plasma concentrations of both (R)- (the active enantiomer) and (S)-MTD were increased by FLV, whereas only (R)-MTD concentrations were increased by the addition of FLX. This suggests that cytochrome P450IID6 (CYP2D6), an enzyme that is strongly inhibited by FLX, preferentially metabolizes (R)-MTD, whereas CYP1A2, which is strongly inhibited by FLV, metabolizes both enantiomers. The choice of a selective serotonin reuptake inhibitor in depressive addicted patients treated with MTD and the possible use of FLX or FLV to potentiate the effects of MTD in some cases of therapeutic failure are discussed.
Mots-clé
Fluoxetine/pharmacokinetics, Fluoxetine/therapeutic use, Fluvoxamine/pharmacokinetics, Fluvoxamine/therapeutic use, Humans, Methadone/pharmacokinetics, Methadone/therapeutic use, Narcotics/pharmacokinetics, Narcotics/therapeutic use, Serotonin Uptake Inhibitors/pharmacokinetics, Serotonin Uptake Inhibitors/therapeutic use, Statistics, Nonparametric, Stereoisomerism, Substance-Related Disorders/blood, Substance-Related Disorders/rehabilitation
Pubmed
Web of science
Création de la notice
01/03/2013 11:49
Dernière modification de la notice
20/08/2019 15:21
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