Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.

Details

Serval ID
serval:BIB_654FBC87007F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.
Journal
Journal of Clinical Psychopharmacology
Author(s)
Eap C.B., Bertschy G., Powell K., Baumann P.
ISSN
0271-0749 (Print)
ISSN-L
0271-0749
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
17
Number
2
Pages
113-117
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Six and seven addicts treated with racemic methadone (MTD) were comedicated with fluvoxamine (FLV) and fluoxetine (FLX), respectively. The plasma concentrations of both (R)- (the active enantiomer) and (S)-MTD were increased by FLV, whereas only (R)-MTD concentrations were increased by the addition of FLX. This suggests that cytochrome P450IID6 (CYP2D6), an enzyme that is strongly inhibited by FLX, preferentially metabolizes (R)-MTD, whereas CYP1A2, which is strongly inhibited by FLV, metabolizes both enantiomers. The choice of a selective serotonin reuptake inhibitor in depressive addicted patients treated with MTD and the possible use of FLX or FLV to potentiate the effects of MTD in some cases of therapeutic failure are discussed.
Keywords
Fluoxetine/pharmacokinetics, Fluoxetine/therapeutic use, Fluvoxamine/pharmacokinetics, Fluvoxamine/therapeutic use, Humans, Methadone/pharmacokinetics, Methadone/therapeutic use, Narcotics/pharmacokinetics, Narcotics/therapeutic use, Serotonin Uptake Inhibitors/pharmacokinetics, Serotonin Uptake Inhibitors/therapeutic use, Statistics, Nonparametric, Stereoisomerism, Substance-Related Disorders/blood, Substance-Related Disorders/rehabilitation
Pubmed
Web of science
Create date
01/03/2013 10:49
Last modification date
20/08/2019 14:21
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