Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Détails
ID Serval
serval:BIB_642E81C4E644
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Périodique
Nature Neuroscience
ISSN
1097-6256 (Print)
Statut éditorial
Publié
Date de publication
11/2004
Volume
7
Numéro
11
Pages
1184-6
Notes
Comparative Study
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Résumé
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.
Mots-clé
Afferent Pathways/physiology
Analysis of Variance
Animals
Cell Size
Cell Surface Extensions/*physiology
Chi-Square Distribution
Interneurons/physiology
Mice
Mice, Transgenic
Models, Neurological
Organ Culture Techniques
Parvalbumins/genetics
Pyramidal Cells/cytology/*physiology
Somatostatin/genetics
Synapses/classification/*physiology
Thalamus/*physiology
Visual Cortex/*cytology/physiology
gamma-Aminobutyric Acid/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:41
Dernière modification de la notice
20/08/2019 15:20