Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Details
Serval ID
serval:BIB_642E81C4E644
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Journal
Nature Neuroscience
ISSN
1097-6256 (Print)
Publication state
Published
Issued date
11/2004
Volume
7
Number
11
Pages
1184-6
Notes
Comparative Study
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Abstract
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.
Keywords
Afferent Pathways/physiology
Analysis of Variance
Animals
Cell Size
Cell Surface Extensions/*physiology
Chi-Square Distribution
Interneurons/physiology
Mice
Mice, Transgenic
Models, Neurological
Organ Culture Techniques
Parvalbumins/genetics
Pyramidal Cells/cytology/*physiology
Somatostatin/genetics
Synapses/classification/*physiology
Thalamus/*physiology
Visual Cortex/*cytology/physiology
gamma-Aminobutyric Acid/*metabolism
Pubmed
Web of science
Create date
24/01/2008 15:41
Last modification date
20/08/2019 15:20