Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates.

Détails

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ID Serval
serval:BIB_63B487FEFFA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates.
Périodique
International Journal of Legal Medicine
Auteur⸱e⸱s
Palmiere C., Mangin P., Werner D.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
2013
Volume
127
Numéro
5
Pages
943-949
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The concentrations of 3-beta-hydroxybutyrate (3HB) in blood and two liver samples were retrospectively examined in a series of medicolegal autopsies. These cases included diabetic ketoacidosis, nondiabetic individuals presenting moderate to severe decompositional changes and nondiabetic medicolegal cases privy of decompositional changes. 3HB concentrations in liver sample homogenates correlate well with blood values in all examined groups. Additionally, decompositional changes were not associated with increases in blood and liver 3HB levels. These results suggest that 3HB can be reliably measured in liver homogenates when blood is not available at autopsy. Furthermore, they suggest that metabolic disturbances potentially leading or contributing to death may be objectified through liver 3HB determination even in decomposed bodies.
Mots-clé
Postmortem biochemistry, 3-Beta-hydroxybutyrate, Liver, Diabetes, Ketoacidosis
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/09/2013 18:42
Dernière modification de la notice
14/02/2022 7:55
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