Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates.

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Serval ID
serval:BIB_63B487FEFFA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates.
Journal
International Journal of Legal Medicine
Author(s)
Palmiere C., Mangin P., Werner D.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Publication state
Published
Issued date
2013
Volume
127
Number
5
Pages
943-949
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The concentrations of 3-beta-hydroxybutyrate (3HB) in blood and two liver samples were retrospectively examined in a series of medicolegal autopsies. These cases included diabetic ketoacidosis, nondiabetic individuals presenting moderate to severe decompositional changes and nondiabetic medicolegal cases privy of decompositional changes. 3HB concentrations in liver sample homogenates correlate well with blood values in all examined groups. Additionally, decompositional changes were not associated with increases in blood and liver 3HB levels. These results suggest that 3HB can be reliably measured in liver homogenates when blood is not available at autopsy. Furthermore, they suggest that metabolic disturbances potentially leading or contributing to death may be objectified through liver 3HB determination even in decomposed bodies.
Keywords
Postmortem biochemistry, 3-Beta-hydroxybutyrate, Liver, Diabetes, Ketoacidosis
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2013 18:42
Last modification date
01/10/2019 6:18
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