Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions?

Détails

ID Serval
serval:BIB_633C8525BEAF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions?
Périodique
Critical Reviews in Oncology/hematology
Auteur(s)
Guiu S., Wolfer A., Jacot W., Fumoleau P., Romieu G., Bonnetain F., Fiche M.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
92
Numéro
3
Pages
235-257
Langue
anglais
Notes
Publication types: REVIEWPublication Status: ppublish
Résumé
The WHO classification of breast tumors distinguishes, besides invasive breast cancer 'of no special type' (former invasive ductal carcinoma, representing 60-70% of all breast cancers), 30 special types, of which invasive lobular carcinoma (ILC) is the most common (5-15%). We review the literature on (i) the specificity and heterogeneity of ILC biology as documented by various analytical techniques, including the results of molecular testing for risk of recurrence; (ii) the impact of lobular histology on prediction of prognosis and effect of systemic therapies in patients. Though it is generally admitted that ILC has a better prognosis than IDC, is endocrine responsive, and responds poorly to chemotherapy, currently available data do not unanimously support these assumptions. This review demonstrates some lack of specific data and a need for improving clinical research design to allow oncologists to make informed systemic therapy decisions in patients with ILC. Importantly, future studies should compare various endpoints in ILC breast cancer patients among the group of hormonosensitive breast cancer.
Mots-clé
Invasive breast cancer, Invasive lobular carcinoma, Luminal breast cancer, Pleomorphic invasive lobular carcinoma, Predictive factor, Prognosis, Tubulo-lobular carcinoma
Pubmed
Web of science
Création de la notice
19/08/2014 14:38
Dernière modification de la notice
20/08/2019 15:19
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