Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions?

Details

Serval ID
serval:BIB_633C8525BEAF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions?
Journal
Critical Reviews in Oncology/hematology
Author(s)
Guiu S., Wolfer A., Jacot W., Fumoleau P., Romieu G., Bonnetain F., Fiche M.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
92
Number
3
Pages
235-257
Language
english
Notes
Publication types: REVIEWPublication Status: ppublish
Abstract
The WHO classification of breast tumors distinguishes, besides invasive breast cancer 'of no special type' (former invasive ductal carcinoma, representing 60-70% of all breast cancers), 30 special types, of which invasive lobular carcinoma (ILC) is the most common (5-15%). We review the literature on (i) the specificity and heterogeneity of ILC biology as documented by various analytical techniques, including the results of molecular testing for risk of recurrence; (ii) the impact of lobular histology on prediction of prognosis and effect of systemic therapies in patients. Though it is generally admitted that ILC has a better prognosis than IDC, is endocrine responsive, and responds poorly to chemotherapy, currently available data do not unanimously support these assumptions. This review demonstrates some lack of specific data and a need for improving clinical research design to allow oncologists to make informed systemic therapy decisions in patients with ILC. Importantly, future studies should compare various endpoints in ILC breast cancer patients among the group of hormonosensitive breast cancer.
Keywords
Invasive breast cancer, Invasive lobular carcinoma, Luminal breast cancer, Pleomorphic invasive lobular carcinoma, Predictive factor, Prognosis, Tubulo-lobular carcinoma
Pubmed
Web of science
Create date
19/08/2014 13:38
Last modification date
20/08/2019 14:19
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