Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.

Détails

ID Serval
serval:BIB_62438E33F313
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.
Périodique
Antimicrobial Agents and Chemotherapy
Auteur(s)
Vermot D., Entenza J.M., Vouillamoz J., Glauser M.P., Moreillon P.
ISSN
0066-4804 (Print)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
1996
Volume
40
Numéro
3
Pages
809-811
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.
Mots-clé
Animals, Anti-Bacterial Agents/therapeutic use, Clarithromycin/therapeutic use, Clindamycin/therapeutic use, Colony Count, Microbial, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/prevention & control, Erythromycin/therapeutic use, Rats, Serum Bactericidal Test, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control
Pubmed
Web of science
Création de la notice
24/01/2008 13:45
Dernière modification de la notice
20/08/2019 14:19
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