Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.

Details

Serval ID
serval:BIB_62438E33F313
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Vermot D., Entenza J.M., Vouillamoz J., Glauser M.P., Moreillon P.
ISSN
0066-4804 (Print)
ISSN-L
0066-4804
Publication state
Published
Issued date
1996
Volume
40
Number
3
Pages
809-811
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.
Keywords
Animals, Anti-Bacterial Agents/therapeutic use, Clarithromycin/therapeutic use, Clindamycin/therapeutic use, Colony Count, Microbial, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/prevention & control, Erythromycin/therapeutic use, Rats, Serum Bactericidal Test, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control
Pubmed
Web of science
Create date
24/01/2008 14:45
Last modification date
20/08/2019 15:19
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