Signification diagnostique et pronostique de l'analyse cytogénétique dans les leucémies aiguës et les syndromes myélodysplasiques. [Significance, diagnosis and prognosis in the cytogenetic analysis in acute leukemias and myelodysplastic syndromes].

Détails

ID Serval
serval:BIB_6221
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Signification diagnostique et pronostique de l'analyse cytogénétique dans les leucémies aiguës et les syndromes myélodysplasiques. [Significance, diagnosis and prognosis in the cytogenetic analysis in acute leukemias and myelodysplastic syndromes].
Périodique
Therapeutische Umschau. Revue Thérapeutique
Auteur(s)
Jotterand Bellomo M.
ISSN
0040-5930 (Print)
ISSN-L
0040-5930
Statut éditorial
Publié
Date de publication
1996
Volume
53
Numéro
2
Pages
103-110
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Cytogenetic analysis of leukemic cells has been shown to be a mandatory part of the diagnosis of malignant hemopathies. Recurring abnormalities may be divided into those exclusively found in myeloid disorders, those associated with lymphoid diseases and those detected in both types of hemopathy. Several of the common defects are characteristic of specific FAB types or subtypes and associated with clinico-pathologic manifestations. Cytogenetic abnormalities have served to identify relatively homogenous subsets of malignant hemopathies. In view of the significant progress realized in the treatment of malignant hemopathies, the assessment of prognostic factors is particularly important for therapeutic decision making. The chromosome status at diagnosis has proven to be a major prognostic indicator for survival and outcome in individual patients. This article will focus on the diagnostic and prognostic significance of the karyotype in de novo acute leukemia and primary myelodysplastic syndromes.
Mots-clé
Acute Disease, Child, Child, Preschool, Chromosome Aberrations, Humans, Infant, Karyotyping, Leukemia/diagnosis, Leukemia/genetics, Myelodysplastic Syndromes/diagnosis, Myelodysplastic Syndromes/genetics, Prognosis
Pubmed
Création de la notice
19/11/2007 12:43
Dernière modification de la notice
20/08/2019 14:19
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