Signification diagnostique et pronostique de l'analyse cytogénétique dans les leucémies aiguës et les syndromes myélodysplasiques. [Significance, diagnosis and prognosis in the cytogenetic analysis in acute leukemias and myelodysplastic syndromes].
Details
Serval ID
serval:BIB_6221
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Signification diagnostique et pronostique de l'analyse cytogénétique dans les leucémies aiguës et les syndromes myélodysplasiques. [Significance, diagnosis and prognosis in the cytogenetic analysis in acute leukemias and myelodysplastic syndromes].
Journal
Therapeutische Umschau. Revue Thérapeutique
ISSN
0040-5930 (Print)
ISSN-L
0040-5930
Publication state
Published
Issued date
1996
Volume
53
Number
2
Pages
103-110
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Cytogenetic analysis of leukemic cells has been shown to be a mandatory part of the diagnosis of malignant hemopathies. Recurring abnormalities may be divided into those exclusively found in myeloid disorders, those associated with lymphoid diseases and those detected in both types of hemopathy. Several of the common defects are characteristic of specific FAB types or subtypes and associated with clinico-pathologic manifestations. Cytogenetic abnormalities have served to identify relatively homogenous subsets of malignant hemopathies. In view of the significant progress realized in the treatment of malignant hemopathies, the assessment of prognostic factors is particularly important for therapeutic decision making. The chromosome status at diagnosis has proven to be a major prognostic indicator for survival and outcome in individual patients. This article will focus on the diagnostic and prognostic significance of the karyotype in de novo acute leukemia and primary myelodysplastic syndromes.
Keywords
Acute Disease, Child, Child, Preschool, Chromosome Aberrations, Humans, Infant, Karyotyping, Leukemia/diagnosis, Leukemia/genetics, Myelodysplastic Syndromes/diagnosis, Myelodysplastic Syndromes/genetics, Prognosis
OAI-PMH
Pubmed
Create date
19/11/2007 13:43
Last modification date
20/08/2019 15:19