In vitro and in vivo Repair Activities of Undifferentiated and Classically and Alternatively Activated Macrophages.

Détails

ID Serval
serval:BIB_61F3BB06DA50
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vitro and in vivo Repair Activities of Undifferentiated and Classically and Alternatively Activated Macrophages.
Périodique
Pathobiology
Auteur⸱e⸱s
Enderlin Vaz da Silva Z., Lehr H.A., Velin D.
ISSN
1423-0291 (Electronic)
ISSN-L
1015-2008
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
81
Numéro
2
Pages
86-93
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Objective: Macrophages play a critical role in wound repair. However, the specific role of the different macrophage subtypes in wound repair remains incompletely understood. The aim of this study was to compare the wound repair activities of undifferentiated macrophages (M0), classically activated macrophages (M1) and alternatively activated (M2) macrophages. Methods: The macrophage repair activities of intestinal wounds were evaluated using in vitro and in vivo models. Results: All three macrophage subtypes enhanced wound closure in vitro, with the M2 macrophages demonstrating greater repair activities than the M0 and M1 macrophages. Injection of M0 and M2 macrophages into mice with experimental dextran sodium sulfate-induced colitis significantly enhanced ulcer repair when compared to control mice. In contrast, injection of M1 macrophages did not affect ulcer repair. Conclusions: These results underscore the wound repair capacity of different macrophage subsets. Notably, wound repair activity is not restricted to M2 macrophages, as the current literature suggests. © 2014 S. Karger AG, Basel.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/03/2014 18:58
Dernière modification de la notice
20/08/2019 14:18
Données d'usage