In vitro and in vivo Repair Activities of Undifferentiated and Classically and Alternatively Activated Macrophages.
Details
Serval ID
serval:BIB_61F3BB06DA50
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vitro and in vivo Repair Activities of Undifferentiated and Classically and Alternatively Activated Macrophages.
Journal
Pathobiology
ISSN
1423-0291 (Electronic)
ISSN-L
1015-2008
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
81
Number
2
Pages
86-93
Language
english
Notes
Publication types: Journal Article
Abstract
Objective: Macrophages play a critical role in wound repair. However, the specific role of the different macrophage subtypes in wound repair remains incompletely understood. The aim of this study was to compare the wound repair activities of undifferentiated macrophages (M0), classically activated macrophages (M1) and alternatively activated (M2) macrophages. Methods: The macrophage repair activities of intestinal wounds were evaluated using in vitro and in vivo models. Results: All three macrophage subtypes enhanced wound closure in vitro, with the M2 macrophages demonstrating greater repair activities than the M0 and M1 macrophages. Injection of M0 and M2 macrophages into mice with experimental dextran sodium sulfate-induced colitis significantly enhanced ulcer repair when compared to control mice. In contrast, injection of M1 macrophages did not affect ulcer repair. Conclusions: These results underscore the wound repair capacity of different macrophage subsets. Notably, wound repair activity is not restricted to M2 macrophages, as the current literature suggests. © 2014 S. Karger AG, Basel.
Pubmed
Web of science
Open Access
Yes
Create date
21/03/2014 19:58
Last modification date
20/08/2019 15:18