ECETOC TRAv3: An In-depth Comparison of Publicly Available Measurement Data Sets With Modelled Estimates of Occupational Inhalation Exposure to Chemicals.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_61277BA12413
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
ECETOC TRAv3: An In-depth Comparison of Publicly Available Measurement Data Sets With Modelled Estimates of Occupational Inhalation Exposure to Chemicals.
Périodique
Annals of work exposures and health
Auteur⸱e⸱s
Savic N., Urbanus J., Henschel O., Li Q., Marsh D., Money C., Noij D., van de Sandt P., van Rooij J., Wormuth M.
ISSN
2398-7316 (Electronic)
ISSN-L
2398-7308
Statut éditorial
Publié
Date de publication
21/04/2023
Peer-reviewed
Oui
Volume
67
Numéro
4
Pages
496-507
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In this study, 129 exposure situations (ESs) with six or more measured inhalation exposures to dust from solids or vapour from liquids in occupational settings were compared with modelled European Centre of Ecotoxicology and Toxicology of Chemicals (ECETOC) targeted risk assessment tool, version 3 (TRAv3) estimates. The measurement data were extracted from previously published studies examining TRAv3 performance and pooled into a curated database. The comparison exercise focussed on the vapour exposure scenarios, as there were too few dust scenarios for a meaningful analysis of any required model corrections. A group of experts in the exposure modelling field retrieved and reviewed the input parameters used in these ESs. Where considered appropriate, modifications were applied to better match the input parameter definitions and the scope of applicability of the TRAv3. Differences and mean absolute error (MAE) were calculated between the log-transformed modelled exposure value and the 75th percentile of each measured data set and regression analysis was performed. The results indicated that the TRAv3 overestimated 80% of the measured data sets. Both over- and underestimations were mostly by factors 1-5. The calculated MAE for liquids was 0.7, indicating that on average the difference between the 75th percentile and the TRAv3 estimate was less than one order of magnitude. A multiple linear regression showed that some input parameters such as medium volatility, certain process categories (PROC), industrial setting, and the presence of local exhaust ventilation are associated with underestimations. The results of the regression analysis can be used by TRAv3 users to review the degree of over- or underestimation in their current exposure assessments, compared to the curated database. Although multiple linear regression is an appropriate methodology to characterize the TRAv3's performance, more data sets are still needed in view of some remaining data gaps. Nevertheless, the results of the current analysis are being used by ECETOC to further develop the tool as a suitably conservative screening tool for use in REACH chemical safety assessment of occupational exposure to chemicals.
Mots-clé
Humans, Occupational Exposure/analysis, Ecotoxicology, Inhalation Exposure/analysis, Regression Analysis, Risk Assessment/methods, Dust, EU chemical regulation, exposure model, regulatory risk assessment, tiered exposure assessment
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/02/2023 14:41
Dernière modification de la notice
09/08/2024 15:00
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