Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.

Détails

ID Serval
serval:BIB_6084ED0FA2FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.
Périodique
American Journal of Clinical Pathology
Auteur⸱e⸱s
Lehr H.A., Folpe A., Yaziji H., Kommoss F., Gown A.M.
ISSN
0002-9173 (Print)
ISSN-L
0002-9173
Statut éditorial
Publié
Date de publication
2000
Volume
114
Numéro
2
Pages
190-196
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Immunohistochemistry using antibodies to cytokeratin 8 can serve as a valuable diagnostic tool for the differentiation of lobular from ductal carcinomas of the breast. In contrast with ductal carcinomas, which exhibit a peripheral-predominant immunostaining pattern, adjacent tumor cells "molding" to each other, lobular carcinomas exhibit a ring-like perinuclear immunostaining pattern, creating a "bag of marbles" appearance with neighboring tumor cells. This immunostaining pattern is stable even in the tumors that otherwise do not exhibit characteristic histomorphologic features (i.e., solid or pleomorphic type of a lobular carcinoma) and tumors that mimic growth patterns characteristic of the respective other tumor type (i.e., targetoid or single-file growth pattern in a ductal carcinoma). Furthermore, we demonstrate that ductal carcinomas express E-cadherin in a similar peripheral-predominant immunostaining pattern (33/33 cases), while all 15 lobular carcinomas were negative for E-cadherin, suggesting a role for E-cadherin in the architectural organization of the cytoskeletal scaffolding within the tumor cells.
Mots-clé
Breast Neoplasms/diagnosis, Breast Neoplasms/metabolism, Cadherins/metabolism, Carcinoma, Ductal, Breast/diagnosis, Carcinoma, Ductal, Breast/metabolism, Carcinoma, Lobular/diagnosis, Carcinoma, Lobular/metabolism, Cell Nucleus/ultrastructure, Diagnosis, Differential, Female, Humans, Immunoenzyme Techniques, Intermediate Filaments/ultrastructure, Keratins/metabolism
Pubmed
Open Access
Oui
Création de la notice
26/11/2011 14:03
Dernière modification de la notice
20/08/2019 15:17
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