Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.

Details

Serval ID
serval:BIB_6084ED0FA2FB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.
Journal
American Journal of Clinical Pathology
Author(s)
Lehr H.A., Folpe A., Yaziji H., Kommoss F., Gown A.M.
ISSN
0002-9173 (Print)
ISSN-L
0002-9173
Publication state
Published
Issued date
2000
Volume
114
Number
2
Pages
190-196
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Immunohistochemistry using antibodies to cytokeratin 8 can serve as a valuable diagnostic tool for the differentiation of lobular from ductal carcinomas of the breast. In contrast with ductal carcinomas, which exhibit a peripheral-predominant immunostaining pattern, adjacent tumor cells "molding" to each other, lobular carcinomas exhibit a ring-like perinuclear immunostaining pattern, creating a "bag of marbles" appearance with neighboring tumor cells. This immunostaining pattern is stable even in the tumors that otherwise do not exhibit characteristic histomorphologic features (i.e., solid or pleomorphic type of a lobular carcinoma) and tumors that mimic growth patterns characteristic of the respective other tumor type (i.e., targetoid or single-file growth pattern in a ductal carcinoma). Furthermore, we demonstrate that ductal carcinomas express E-cadherin in a similar peripheral-predominant immunostaining pattern (33/33 cases), while all 15 lobular carcinomas were negative for E-cadherin, suggesting a role for E-cadherin in the architectural organization of the cytoskeletal scaffolding within the tumor cells.
Keywords
Breast Neoplasms/diagnosis, Breast Neoplasms/metabolism, Cadherins/metabolism, Carcinoma, Ductal, Breast/diagnosis, Carcinoma, Ductal, Breast/metabolism, Carcinoma, Lobular/diagnosis, Carcinoma, Lobular/metabolism, Cell Nucleus/ultrastructure, Diagnosis, Differential, Female, Humans, Immunoenzyme Techniques, Intermediate Filaments/ultrastructure, Keratins/metabolism
Pubmed
Open Access
Yes
Create date
26/11/2011 13:03
Last modification date
20/08/2019 14:17
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