Postoperative 3D conformal RT (PORT) in non small cell lung cancer (NSCLC)
Détails
ID Serval
serval:BIB_600E08A9B93A
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Postoperative 3D conformal RT (PORT) in non small cell lung cancer (NSCLC)
Titre de la conférence
11th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO)
Adresse
Aarau, Switzerland, March 15-17, 2007
ISSN
0179-7158
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
183
Numéro
Suppl. 1
Série
Strahlentherapie und Onkologie
Pages
173
Langue
anglais
Résumé
Objective: To assess the outcome of patients treated with involved-field PORT for NSCLC.
Material and Methods: From September 1996 to 2006, data from 75 patients (pts) treated with curative surgery and PORT for
NSCLC were retrospectively analyzed. Median age was 58 years (range, 38-76). There were 5 pts with stage I, 22 with stage II, and 48 with stage III disease. Pneumonectomy or lobectomy was realized in 24 (32%) and 51 (68%) pts, respectively. Adjuvant chemotherapy was given in 15 (20%). All pts had 3D conformal planning.
Median RT dose was 60 Gy, and CTV included bronchial stump and only positive nodal areas.
Results: All pts have completed full treatment. With a median follow-up of 55 months, 26 pts are alive without disease. Median overall survival time was 24 months, with survival rate of 35% at 5 years. The 5-year locoregional control and distant disease-free rates were 80% and 57%, respectively. Pts treated with pneumonectomy and those treated with at least 60-Gy PORT had better outcome. Grade 3 or more CTC v3.0 toxicity was observed only in 4 (5%) pts.
Conclusion: We conclude that involved-field 3D conformal 60-Gy PORT increase significantly locoregional control without increasing lethal toxicity.
Material and Methods: From September 1996 to 2006, data from 75 patients (pts) treated with curative surgery and PORT for
NSCLC were retrospectively analyzed. Median age was 58 years (range, 38-76). There were 5 pts with stage I, 22 with stage II, and 48 with stage III disease. Pneumonectomy or lobectomy was realized in 24 (32%) and 51 (68%) pts, respectively. Adjuvant chemotherapy was given in 15 (20%). All pts had 3D conformal planning.
Median RT dose was 60 Gy, and CTV included bronchial stump and only positive nodal areas.
Results: All pts have completed full treatment. With a median follow-up of 55 months, 26 pts are alive without disease. Median overall survival time was 24 months, with survival rate of 35% at 5 years. The 5-year locoregional control and distant disease-free rates were 80% and 57%, respectively. Pts treated with pneumonectomy and those treated with at least 60-Gy PORT had better outcome. Grade 3 or more CTC v3.0 toxicity was observed only in 4 (5%) pts.
Conclusion: We conclude that involved-field 3D conformal 60-Gy PORT increase significantly locoregional control without increasing lethal toxicity.
Web of science
Création de la notice
28/04/2008 11:35
Dernière modification de la notice
20/08/2019 15:17
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