Tissue- and column-specific measurements from multi-parameter mapping of the human cervical spinal cord at 3 T.

Détails

ID Serval
serval:BIB_5F2EA4BDE556
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tissue- and column-specific measurements from multi-parameter mapping of the human cervical spinal cord at 3 T.
Périodique
Nmr in Biomedicine
Auteur(s)
Samson R.S., Ciccarelli O., Kachramanoglou C., Brightman L., Lutti A., Thomas D.L., Weiskopf N., Wheeler-Kingshott C.A.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
26
Numéro
12
Pages
1823-1830
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
The aim of this study was to quantify a range of MR parameters [apparent proton density, longitudinal relaxation time T1, magnetisation transfer (MT) ratio, MT saturation (which represents the additional percentage MT saturation of the longitudinal magnetisation caused by a single MT pulse) and apparent transverse relaxation rate R2*] in the white matter columns and grey matter of the healthy cervical spinal cord. The cervical cords of 13 healthy volunteers were scanned at 3 T using a protocol optimised for multi-parameter mapping. Intra-subject co-registration was performed using linear registration, and tissue- and column-specific parameter values were calculated. Cervical cord parameter values measured from levels C1-C5 in 13 subjects are: apparent proton density, 4822 ± 718 a.u.; MT ratio, 40.4 ± 1.53 p.u.; MT saturation, 1.40 ± 0.12 p.u.; T1 = 1848 ± 143 ms; R2* = 22.6 ± 1.53 s(-1). Inter-subject coefficients of variation were low in both the cervical cord and tissue- and column-specific measurements, illustrating the potential of this method for the investigation of changes in these parameters caused by pathology. In summary, an optimised cervical cord multi-parameter mapping protocol was developed, enabling tissue- and column-specific measurements to be made. This technique has the potential to provide insight into the pathological processes occurring in the cervical cord affected by neurological disorders.
Mots-clé
Adult, Cervical Vertebrae/pathology, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Organ Specificity, Spinal Cord/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/10/2014 11:13
Dernière modification de la notice
20/08/2019 15:16
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