Tissue- and column-specific measurements from multi-parameter mapping of the human cervical spinal cord at 3 T.
Details
Serval ID
serval:BIB_5F2EA4BDE556
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tissue- and column-specific measurements from multi-parameter mapping of the human cervical spinal cord at 3 T.
Journal
Nmr in Biomedicine
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
26
Number
12
Pages
1823-1830
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
The aim of this study was to quantify a range of MR parameters [apparent proton density, longitudinal relaxation time T1, magnetisation transfer (MT) ratio, MT saturation (which represents the additional percentage MT saturation of the longitudinal magnetisation caused by a single MT pulse) and apparent transverse relaxation rate R2*] in the white matter columns and grey matter of the healthy cervical spinal cord. The cervical cords of 13 healthy volunteers were scanned at 3 T using a protocol optimised for multi-parameter mapping. Intra-subject co-registration was performed using linear registration, and tissue- and column-specific parameter values were calculated. Cervical cord parameter values measured from levels C1-C5 in 13 subjects are: apparent proton density, 4822 ± 718 a.u.; MT ratio, 40.4 ± 1.53 p.u.; MT saturation, 1.40 ± 0.12 p.u.; T1 = 1848 ± 143 ms; R2* = 22.6 ± 1.53 s(-1). Inter-subject coefficients of variation were low in both the cervical cord and tissue- and column-specific measurements, illustrating the potential of this method for the investigation of changes in these parameters caused by pathology. In summary, an optimised cervical cord multi-parameter mapping protocol was developed, enabling tissue- and column-specific measurements to be made. This technique has the potential to provide insight into the pathological processes occurring in the cervical cord affected by neurological disorders.
Keywords
Adult, Cervical Vertebrae/pathology, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Organ Specificity, Spinal Cord/pathology
Pubmed
Web of science
Open Access
Yes
Create date
20/10/2014 10:13
Last modification date
20/08/2019 14:16