Molecular cloning of interferon receptors: a short review.

Détails

ID Serval
serval:BIB_5EEB940B0541
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular cloning of interferon receptors: a short review.
Périodique
British Journal of Haematology
Auteur(s)
Aguet M.
ISSN
0007-1048 (Print)
ISSN-L
0007-1048
Statut éditorial
Publié
Date de publication
1991
Volume
79
Numéro
Suppl 1
Pages
6-8
Langue
anglais
Résumé
Interferons (IFNs) exert their pleiotropic effects through at least two different receptors. IFNs alpha/beta (type I IFNs) crossreact with presumably common receptors, while IFN gamma (type II IFN) initiates its biological effects through its own specific receptor system. Transmembrane proteins corresponding to the ligand binding chains of these receptors have recently been cloned. But transfection experiments revealed that additional components are probably involved in high affinity binding of some type I IFN subtypes and that a species specific putative signal transducer is required to confer biological responsiveness to IFN gamma. Although some elements involved in transcriptional regulation of interferon inducible genes have been identified, the pathways involved in these regulatory processes are not understood as yet. The current knowledge on the structure of IFN receptors is reviewed in the context of some recent advances on other cytokine receptors.
Mots-clé
Animals, Cloning, Molecular, Humans, Interferon-alpha/metabolism, Interferon-gamma/metabolism, Mice, Receptors, Immunologic/genetics, Receptors, Interferon
Pubmed
Web of science
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
20/08/2019 15:16
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