Molecular cloning of interferon receptors: a short review.

Details

Serval ID
serval:BIB_5EEB940B0541
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Molecular cloning of interferon receptors: a short review.
Journal
British Journal of Haematology
Author(s)
Aguet M.
ISSN
0007-1048 (Print)
ISSN-L
0007-1048
Publication state
Published
Issued date
1991
Volume
79
Number
Suppl 1
Pages
6-8
Language
english
Abstract
Interferons (IFNs) exert their pleiotropic effects through at least two different receptors. IFNs alpha/beta (type I IFNs) crossreact with presumably common receptors, while IFN gamma (type II IFN) initiates its biological effects through its own specific receptor system. Transmembrane proteins corresponding to the ligand binding chains of these receptors have recently been cloned. But transfection experiments revealed that additional components are probably involved in high affinity binding of some type I IFN subtypes and that a species specific putative signal transducer is required to confer biological responsiveness to IFN gamma. Although some elements involved in transcriptional regulation of interferon inducible genes have been identified, the pathways involved in these regulatory processes are not understood as yet. The current knowledge on the structure of IFN receptors is reviewed in the context of some recent advances on other cytokine receptors.
Keywords
Animals, Cloning, Molecular, Humans, Interferon-alpha/metabolism, Interferon-gamma/metabolism, Mice, Receptors, Immunologic/genetics, Receptors, Interferon
Pubmed
Web of science
Create date
28/01/2008 11:36
Last modification date
20/08/2019 14:16
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