High-sensitive cardiac troponin hs-TnT levels in sudden death related to atherosclerotic coronary artery disease

Détails

Ressource 1Télécharger: Mémoire no 2463 M. Beausire.pdf (459.87 [Ko])
Etat: Public
Version: Après imprimatur
Licence: Non spécifiée
ID Serval
serval:BIB_5EEA74DCB92D
Type
Mémoire
Sous-type
(Mémoire de) maîtrise (master)
Collection
Publications
Institution
Titre
High-sensitive cardiac troponin hs-TnT levels in sudden death related to atherosclerotic coronary artery disease
Auteur(s)
BEAUSIRE Tim
Directeur(s)
MICHAUD Katarzyna
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Acceptée
Date de publication
2017
Langue
anglais
Nombre de pages
17
Résumé
ABSTRACT
INTRODUCTION: Ischemic heart disease (IHD) related to atherosclerotic coronary artery disease (CAD) is one of the most prevalent causes of death in Europe. Also post-mortem evaluation of IHD remains a challenge because of possible non-specific autopsy finding in some autopsy cases, especially in early myocardial ischemia. High-sensitive troponin T (hs- TnT) is used today in clinical practice as the “gold standard” to diagnose the myocardial ischemia, and might also be applied as an ancillary tool for post-mortem evaluation.
PURPOSE: The goal of this study is to evaluate the diagnostic value of post-mortem serum hs-TnT assay in cases of sudden death related to IHD. We will also investigate the influence of cardiopulmonary resuscitation (CPR) attempts on post-mortem hs-TnT levels.
METHODS: The hs-TnT values in serum were retrospectively analysed in 85 autopsy data (2012-2015, University Center of Legal Medicine in Lausanne). 52 cases with clinical history and morphological results suggesting cardiac ischemia were included in the study group (mean age 53.5; age range 34-75), 33 in the control group (mean age 40.4; age range 15-69). The group’s statistical comparison was performed using logistic regression model.
RESULTS: Our study showed a significant non-linear association between hs-TnT serum values and post-mortem diagnosis of sudden deaths related to IHD (p-value 0.005). The shape of the relationship is showing that the probability of death due to IHD increases quickly with a light level of hs-TnT (maximum around 90ng/L), then decreases slightly while remaining at high in values. No significant difference in the hs-TnT serum values was found between the CPR and the non-CPR cases (p-value 0.304).
CONCLUSION: The measurement of Hs-TnT serum values might be considered as an ancillary tool for the evaluation of death related to IHD, while taking necessary precautions in the interpretation of the results.
Mots-clé
High-sensitive cardiac troponin hs-TnT, sudden death, myocardial ischemia
Création de la notice
05/09/2018 10:48
Dernière modification de la notice
08/09/2020 7:09
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