High-sensitive cardiac troponin hs-TnT levels in sudden death related to atherosclerotic coronary artery disease

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Serval ID
serval:BIB_5EEA74DCB92D
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
High-sensitive cardiac troponin hs-TnT levels in sudden death related to atherosclerotic coronary artery disease
Author(s)
BEAUSIRE Tim
Director(s)
MICHAUD Katarzyna
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2017
Language
english
Number of pages
17
Abstract
ABSTRACT
INTRODUCTION: Ischemic heart disease (IHD) related to atherosclerotic coronary artery disease (CAD) is one of the most prevalent causes of death in Europe. Also post-mortem evaluation of IHD remains a challenge because of possible non-specific autopsy finding in some autopsy cases, especially in early myocardial ischemia. High-sensitive troponin T (hs- TnT) is used today in clinical practice as the “gold standard” to diagnose the myocardial ischemia, and might also be applied as an ancillary tool for post-mortem evaluation.
PURPOSE: The goal of this study is to evaluate the diagnostic value of post-mortem serum hs-TnT assay in cases of sudden death related to IHD. We will also investigate the influence of cardiopulmonary resuscitation (CPR) attempts on post-mortem hs-TnT levels.
METHODS: The hs-TnT values in serum were retrospectively analysed in 85 autopsy data (2012-2015, University Center of Legal Medicine in Lausanne). 52 cases with clinical history and morphological results suggesting cardiac ischemia were included in the study group (mean age 53.5; age range 34-75), 33 in the control group (mean age 40.4; age range 15-69). The group’s statistical comparison was performed using logistic regression model.
RESULTS: Our study showed a significant non-linear association between hs-TnT serum values and post-mortem diagnosis of sudden deaths related to IHD (p-value 0.005). The shape of the relationship is showing that the probability of death due to IHD increases quickly with a light level of hs-TnT (maximum around 90ng/L), then decreases slightly while remaining at high in values. No significant difference in the hs-TnT serum values was found between the CPR and the non-CPR cases (p-value 0.304).
CONCLUSION: The measurement of Hs-TnT serum values might be considered as an ancillary tool for the evaluation of death related to IHD, while taking necessary precautions in the interpretation of the results.
Keywords
High-sensitive cardiac troponin hs-TnT, sudden death, myocardial ischemia
Create date
05/09/2018 9:48
Last modification date
08/09/2020 6:09
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