Oxysterols in Autoimmunity.

Détails

ID Serval
serval:BIB_5E37F576AD78
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Oxysterols in Autoimmunity.
Périodique
International journal of molecular sciences
Auteur(s)
Duc D., Vigne S., Pot C.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
12/09/2019
Peer-reviewed
Oui
Volume
20
Numéro
18
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Cholesterol is a member of the sterol family that plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized into several molecules including bile acids, hormones, and oxysterols. Studies from the last few decades have demonstrated that oxysterols are not only active metabolites but are further involved in the modulation of immune responses. Liver X Receptors (LXRs), nuclear receptors for oxysterols, are important for cholesterol homeostasis and regulation of inflammatory response but are still poorly characterized during autoimmune diseases. Here we review the current knowledge about the role of oxysterols during autoimmune conditions and focus on the implication of LXR-dependent and LXR-independent pathways. We further highlight the importance of these pathways in particular during central nervous system (CNS) autoimmunity and inflammatory bowel diseases (IBD) in both experimental models and human studies. Finally, we discuss our vision about future applications and research on oxysterols related to autoimmunity.
Mots-clé
Animals, Autoimmune Diseases/immunology, Autoimmunity, Central Nervous System Diseases/immunology, Cholesterol/immunology, Humans, Inflammatory Bowel Diseases/immunology, Liver X Receptors/immunology, Oxysterols/immunology, Ch25h, Ebi2, Liver X receptors, ROR, autoimmunity, inflammatory bowel disease, multiple sclerosis, oxysterols
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/09/2019 8:09
Dernière modification de la notice
07/02/2020 6:19
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