Oxysterols in Autoimmunity.

Details

Serval ID
serval:BIB_5E37F576AD78
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Oxysterols in Autoimmunity.
Journal
International journal of molecular sciences
Author(s)
Duc D., Vigne S., Pot C.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
12/09/2019
Peer-reviewed
Oui
Volume
20
Number
18
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Cholesterol is a member of the sterol family that plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized into several molecules including bile acids, hormones, and oxysterols. Studies from the last few decades have demonstrated that oxysterols are not only active metabolites but are further involved in the modulation of immune responses. Liver X Receptors (LXRs), nuclear receptors for oxysterols, are important for cholesterol homeostasis and regulation of inflammatory response but are still poorly characterized during autoimmune diseases. Here we review the current knowledge about the role of oxysterols during autoimmune conditions and focus on the implication of LXR-dependent and LXR-independent pathways. We further highlight the importance of these pathways in particular during central nervous system (CNS) autoimmunity and inflammatory bowel diseases (IBD) in both experimental models and human studies. Finally, we discuss our vision about future applications and research on oxysterols related to autoimmunity.
Keywords
Animals, Autoimmune Diseases/immunology, Autoimmunity, Central Nervous System Diseases/immunology, Cholesterol/immunology, Humans, Inflammatory Bowel Diseases/immunology, Liver X Receptors/immunology, Oxysterols/immunology, Ch25h, Ebi2, Liver X receptors, ROR, autoimmunity, inflammatory bowel disease, multiple sclerosis, oxysterols
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2019 9:09
Last modification date
07/02/2020 7:19
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