The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity

Détails

ID Serval
serval:BIB_5CE39F592BBB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
Périodique
Molecular Endocrinology
Auteur(s)
Flaster  H., Bernhagen  J., Calandra  T., Bucala  R.
ISSN
0888-8809 (Print)
Statut éditorial
Publié
Date de publication
06/2007
Volume
21
Numéro
6
Pages
1267-80
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun
Résumé
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
Mots-clé
Autoimmune Diseases/therapy Glucocorticoids/*metabolism Humans Immune System/*metabolism Immunity Immunosuppression Inflammation/*immunology Macrophage Migration-Inhibitory Factors/antagonists & inhibitors/genetics/*metabolism Macrophages/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:28
Dernière modification de la notice
20/08/2019 15:15
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