The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
Details
Serval ID
serval:BIB_5CE39F592BBB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
Journal
Molecular Endocrinology
ISSN
0888-8809 (Print)
Publication state
Published
Issued date
06/2007
Volume
21
Number
6
Pages
1267-80
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun
Abstract
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
Keywords
Autoimmune Diseases/therapy
Glucocorticoids/*metabolism
Humans
Immune System/*metabolism
Immunity
Immunosuppression
Inflammation/*immunology
Macrophage Migration-Inhibitory Factors/antagonists &
inhibitors/genetics/*metabolism
Macrophages/immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:28
Last modification date
20/08/2019 15:15
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