Conventional magnetic resonance imaging (MRI) measures
of multiple sclerosis patients provide limited
information about the nature and the extent of brain
damage and repair. We established a clinically compatible
protocol including quantitative MRI techniques (qMRI, T1,
T2, T2* relaxometry) and semiquantitative Magnetisation
Transfer Imaging to provide a comprehensive MRI
fingerprint (CMF) of lesions that is more adherent to the
real underlying pathology and to assess the CMF
contribution to clinical performances in patients.
Lesions characteristics, revealed by combination of q/sq
MRI, highly correlated with patients clinical performance
and more severe lesions appeared to drive the
clinic-radiological correlations.