Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?

Détails

ID Serval
serval:BIB_5A72675F8324
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Bussien  J. P., Waeber  B., Nussberger  J., Schaller  M. D., Gavras  H., Hofbauer  K., Brunner  H. R.
ISSN
0363-6135
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
01/1984
Volume
246
Numéro
1 Pt 2
Pages
H143-7
Notes
Journal Article --- Old month value: Jan
Résumé
The inhibitor of the pressor effect of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, at a dose of 5 micrograms/kg iv was shown in four healthy volunteers to antagonize the blood pressure, heart rate, and skin blood flow response to a lysine vasopressin infusion of 1 mIU X kg-1 X min-1. The inhibition lasted for more than 2 h. When the same dose of the vasopressin antagonist was administered to 10 healthy normally hydrated volunteers with their renin system intact or acutely blocked by 25 mg of captopril po, none of the above parameters changed. It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis.
Mots-clé
Adult Arginine Vasopressin/*analogs & derivatives/pharmacology Blood Pressure/*drug effects Captopril/pharmacology Heart Rate/drug effects Humans Male Regional Blood Flow/drug effects Skin/blood supply
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
20/08/2019 15:13
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