Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?

Details

Serval ID
serval:BIB_5A72675F8324
Type
Article: article from journal or magazin.
Collection
Publications
Title
Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Bussien  J. P., Waeber  B., Nussberger  J., Schaller  M. D., Gavras  H., Hofbauer  K., Brunner  H. R.
ISSN
0363-6135
ISSN-L
0363-6135
Publication state
Published
Issued date
01/1984
Volume
246
Number
1 Pt 2
Pages
H143-7
Notes
Journal Article --- Old month value: Jan
Abstract
The inhibitor of the pressor effect of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, at a dose of 5 micrograms/kg iv was shown in four healthy volunteers to antagonize the blood pressure, heart rate, and skin blood flow response to a lysine vasopressin infusion of 1 mIU X kg-1 X min-1. The inhibition lasted for more than 2 h. When the same dose of the vasopressin antagonist was administered to 10 healthy normally hydrated volunteers with their renin system intact or acutely blocked by 25 mg of captopril po, none of the above parameters changed. It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis.
Keywords
Adult Arginine Vasopressin/*analogs & derivatives/pharmacology Blood Pressure/*drug effects Captopril/pharmacology Heart Rate/drug effects Humans Male Regional Blood Flow/drug effects Skin/blood supply
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 15:13
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